Those who donate blood or lose blood ≥400 mL or have blood transfusion within 3 months before the first administration of the test drug.Any disease history or current disease that may affect the safety evaluation of subjects or the internal process of experimental drugs, including the central nervous system, cardiovascular system, digestive system, respiratory system, urinary system, blood system, immunology, Psychiatry, metabolic abnormalities, gastrointestinal surgery (except appendicitis surgery), etc.Those who use any caffeine-rich food or drink (coffee, tea, cola, chocolate, etc.) within 48 hours before the first administration of the test drug, or who do not agree to prohibit the use of any caffeine-rich food or drink during the test period ；.People with insomnia, anxiety disorder, depression disorder or other mental disorders.QTcF>450 milliseconds (msec) found in the screening period inspection.Clinically significant dizziness or vertigo, or a history of inner ear diseases known to cause dizziness or vertigo.Those who have had angioedema in the past.

Those who have special requirements for diet and cannot comply with a unified diet.

Those who are known to have a history of allergies, allergic diseases or allergies to the research preparation and any of its ingredients or related preparations, or those who have a history of pregabalin or gabapentin allergy.

Agree to have no birth plan and be able to take reliable contraceptive measures within 3 months after the end of the trial Be able to communicate well with researchers, fully understand the purpose and requirements of this trial, voluntarily participate in clinical trials and sign written informed consent.

Physical examination, vital signs, 12-lead electrocardiogram (ECG), chest X-ray (posterior anterior position), and laboratory examination indicators are normal or abnormal and have no clinical significance.

Serum creatinine during the screening period is within the normal range, or creatinine clearance rate (CCr) ≥80mL/min.

Weight: male ≥50 kg, female ≥45kg body mass index (BMI) in the range of 19-28kg/m2 (including 19 and 28).

18-50 years old (including 18 and 50 years old), healthy male or female.

Why Should I Register and Submit Results?.

Hdsentinel trial